Judith Klein-Seetharaman

Associate Professor, Chemistry
Director of Bioscience and Engineering
Judith Klein-Seetharaman

Contact

CoorsTek Hall 202
303-384-2622
judithklein@mines.edu

Education

  • PhD, Biological Chemistry. Massachusetts Institute of Technology, Cambridge, MA (2000)
  • Diplom, Biology, Cologne University, Germany (1996)
  • Diplom, Chemistry, Cologne University, Germany (1995)

Research Areas

  • Identification of biomarkers of weight loss
  • Metaproteomics of microbiome-environment interactions
  • Characterization of denatured states of membrane proteins
  • Understanding mechanisms of allostery in membrane receptors
  • NMR structural analysis of uroplakin proteins and their interactions
  • Biological language modeling of lipids and proteins

Publications

  1. Ye L, Maji S, Sanghera N, Gopalasingam P, Gorbunov E, Tarasov S, Epstein O, Klein-Seetharaman J. Structure and dynamics of the insulin receptor: implications for receptor activation and drug discovery. Drug Discov Today. 2017 Jul;22(7):1092-1102. doi: 10.1016/j.drudis.2017.04.011. Epub 2017 May 3. Review. PubMed PMID: 28476537.
  2. Kshirsagar M, Murugesan K, Carbonell JG, Klein-Seetharaman J. Multitask Matrix Completion for Learning Protein Interactions Across Diseases. J Comput Biol. 2017 Jun;24(6):501-514. doi: 10.1089/cmb.2016.0201. Epub 2017 Jan 27. PubMed PMID:
    28128642.
  3. Insulin biosensor development: a case study. Narinder Sanghera, Alexander Anderson, Nick Nuar, Can Xie, Daniel Mitchell & Judith Klein-Seetharaman. International Journal of Parallel, Emergent and Distributed Systems Vol. 32 , Iss. 1,2017
  4. Woods KN, Pfeffer J, Dutta A, Klein-Seetharaman J. Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors. Sci Rep. 2016 Nov 16;6:37290. doi: 10.1038/srep37290. PubMed PMID: 27849063; PubMed
    Central PMCID: PMC5110974.
  5. Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA,  Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli
    RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. Epub 2016 Nov 14. PubMed PMID: 27842066; PubMed Central
    PMCID: PMC5506843.
  6. Planas-Iglesias J, Dwarakanath H, Mohammadyani D, Yanamala N, Kagan VE, Klein-Seetharaman J. Cardiolipin Interactions with Proteins. Biophys J. 2015 Sep 15;109(6):1282-94. doi: 10.1016/j.bpj.2015.07.034. Epub 2015 Aug 20. PubMed PMID: 26300339; PubMed Central PMCID: PMC4576322.
  7. Additive effects of chlorin e6 and metal ion binding on the thermal stability of rhodopsin in vitro. Balem F, Yanamala N, Klein-Seetharaman J. Photochem Photobiol. 2009 Mar-Apr;85(2):471-8. doi: 10.1111/j.1751-1097.2009.00539.x.
  8. Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors. Yanamala N, Tirupula KC, Klein-Seetharaman J. BMC Bioinformatics. 2008;9 Suppl 1:S16. doi: 10.1186/1471-2105-9-S1-S16.
  9. Evaluation of different biological data and computational classification methods for use in protein interaction prediction. Qi Y, Bar-Joseph Z, Klein-Seetharaman J. Proteins. 2006 May 15;63(3):490-500.
  10. Long-range interactions within a nonnative protein. Klein-Seetharaman J, Oikawa M, Grimshaw SB, Wirmer J, Duchardt E, Ueda T, Imoto T, Smith LJ, Dobson CM, Schwalbe H. Science. 2002 Mar 1;295(5560):1719-22.
  11. NMR spectroscopy in studies of light-induced structural changes in mammalian rhodopsin: applicability of solution (19)F NMR. Klein-Seetharaman J, Getmanova EV, Loewen MC, Reeves PJ, Khorana HG. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13744-9.